Iindaba

Imbali kunye nendaleko ye-inesthesia

Ulawulo lwe-intravenous lweziyobisi luye kwinkulungwane yeshumi elinesixhenxe xa uChristopher Wren of i-opium usebenzisa inja esebenzisa i-goose quill kunye ne-pig i-geg kunye nenja '. Ngeminyaka yee-1930s Hexobarbital kwaye iPentothal yaziswa kunyango lweklinikhi.

Kwakungo-1960s Pharmacokinetic ukuba iimodeli kunye ne-equations ze-IV zisenziwa kwaye ngo-1980s, iinkqubo ezilawulwa ngekhompyuter ze-IV zaziswa. Ngo-1996 i-thagety yokuqala yethagethi ('idiprusisor') yaziswa.

Inkcazo

A Ithagethi ilawulwa ngoxinzelelokukuthathwa kwendlela elawulwa ngolo hlobo malunga nokuzama ukufezekisa uxinzelelo lweziyobisi oluchaziweyo kwicandelo lomzimba okanye izicubu zomdla. Lo mxholo waqala wacebisa ngeKruger Thiemer ngo-1968.

I-pharmacokinetics

Ubungakanani bokuhanjiswa.

Le yivolumu ebonakalayo apho ichiza lisasazwa khona. Ibalwa yifomula: vd = idosi / i-Decection yeziyobisi. Ixabiso layo lixhomekeke ekubeni ibalwa nge-zero-emva kwe-bolus (VC) okanye kwiLizwe eliqinileyo emva kokuhonjiswa (i-VSS).

Imvume.

Ukucocwa kumele ivolumu yeplasma (vp) apho ichiza lisuswa khona kwicandelo ngalinye le-akhawunti yokupheliswa komzimba. Imvume = Ukupheliswa x vp.

Njengoko uCoce uyonyusa isiqingatha sobomi, kwaye njengoko ivolumu yokusasazeka inyuka njalo injalo isiqingatha sobomi. Ukucocwa kunokusetyenziselwa ukuchaza ukuba ichiza lihamba njani phakathi kwezithuthi. Ichiza liqala ngokusasazwa kwicandelo eliphakathi ngaphambi kokusasazwa kwicandelo le-peripheral. Ukuba ivolumu yokuqala yokuhanjiswa (i-VC) kunye ne-Cestical Scieff Isiphumo soNyango (CP) esaziwa (kunokwenzeka ukubala idosi yokulayisha ukuze ifezekise loo msebenzi:

Ukulayisha idosi = cp x vc

Ingasetyenziselwa ukubala idosi yeBols efunekayo ukubandezeleka ngokukhawuleza koxinzelelo ngexesha lokufakwa kwe-influon: i-bosse = (i-cenew-ubuchule) x vc. Ireyithi ye-insulion yokugcina imeko yokuthenga

Iirejimeni ezilula ezilula azifikeleli i-plasma ye-plasma engagungqiyo ide ibe mihlanu iphindaphindwe kabini ngobomi. Uxinzelelo olufunwayo lunokufezekiswa ngakumbi ukuba idosi ye-bolus ilandelwa ngumgangatho we-insusushini.