Iindaba

I-pharmacokineticIimodeli zizama ukuchaza ubudlelwane phakathi kwe-Dose kunye nePlasma ngokubhekisele kwixesha. Imodeli ye-pharmacokinetic yimodeli yemathematics enokusetyenziselwa ukuqikelela iprofayili yegazi yegazi emva kwedosi ye-bos okanye emva kwexesha lokwahluka. Ezi modeli ziqhele ukulinganisa ubugcisa bokulinganisa i-arrial okanye i-vesma yoxinaniso emva kwebhotile okanye i-insulion kwiqela lamavolontiya, esebenzisa iindlela zekhompyuter ezimiselweyo.

Iimodeli zemathematics zivelisa ezinye iiparamitha ze-pharmackicinetic ezinje ngomthamo wokuhanjiswa kunye nokucaciswa. Ezi zinokusetyenziselwa ukubala idosi yokulayisha kunye nenqanaba lokufakwa kwexabiso elifunekayo ukugcina ugxininiso lwe-plasma oluzinzileyo kwi-plasmaibribrium.

Kuba ivunyiwe ukuba i-pharmaconkinetics yearhente ezininzi ze-anestheitic ihambelana nemodeli emithathu ye-commartment, i-algorithms ezininzi yokujolisa igazi kunye nendawo yokugxila kwendawo sele iphuhlisiwe kwaye iinkqubo ezininzi ezenzekelayo ziphuhlisiwe.