PharmacokineticIimodeli zizama ukuchaza ubudlelwane phakathi kwethamo kunye noxinzelelo lweplasma malunga nexesha. Imodeli ye-pharmacokinetic yimodeli yemathematika enokuthi isetyenziswe ukuqikelela iprofayili yoxinaniso lwegazi lwechiza emva kwedosi ye-bolus okanye emva kokufakelwa kobude obahlukeneyo. Ezi modeli ziqhelekile ukuba zithathwe kwifomu yokulinganisa i-arterial okanye i-plasma ye-venous emva kwe-bolus okanye ukufakwa kwiqela lamavolontiya, kusetyenziswa iindlela manani ezisemgangathweni kunye neemodeli zesoftware yekhompyuter.
Iimodeli zemathematika zivelisa ezinye iiparamitha ze-pharmacokinetic ezifana nomthamo wokusasazwa kunye nokukhutshwa. Ezi zingasetyenziselwa ukubala idosi yokulayisha kunye nesantya sokufakwa okuyimfuneko ukuze kugcinwe ukugxininiswa kwe-plasma ezinzileyo ngokulingana.
Ukusukela oko kuye kwaqatshelwa ukuba i-pharmacokinetics yee-agent ezininzi zokuthomalalisa ihambelana kakuhle nemodeli yamacandelo amathathu, uninzi lwe-algorithms yokujolisa kwigazi kunye nesiphumo sokugxila kwindawo sele ipapashiwe kwaye iinkqubo ezininzi ezizenzekelayo ziye zaphuhliswa.
Ixesha lokuposa: Nov-05-2024