Iindaba

I-PharmacokineticIimodeli zizama ukuchaza ubudlelwane phakathi kwedosi kunye noxinzelelo lweplasma malunga nexesha. Imodeli ye-pharmacokinetic yimodeli yezibalo enokusetyenziswa ukuqikelela iprofayili yoxinzelelo lwegazi lweyeza emva kwedosi ye-bolus okanye emva kokufakwa kwexesha elahlukileyo. Ezi modeli zihlala zithathwa ngendlela yokulinganisa uxinano lweplasma yemithambo okanye yemithambo emva kwe-bolus okanye ukufakwa kwiqela lamavolontiya, kusetyenziswa iindlela ezimiselweyo zezibalo kunye neemodeli zesoftware yekhompyutha.

Iimodeli zezibalo zivelisa ezinye iiparameter ze-pharmacokinetic ezifana nomthamo wokusasazwa kunye nokususwa. Ezi zinokusetyenziselwa ukubala idosi yokulayisha kunye nesantya sokufakwa esifunekayo ukugcina uxinzelelo lwe-plasma oluzinzileyo kwi-equilibrium.

Ekubeni kuye kwaqatshelwa ukuba i-pharmacokinetics yee-anesthetic agents ezininzi zihambelana kakuhle nemodeli yecandelo ezintathu, kuye kwapapashwa ii-algorithms ezininzi zokujolisa ubuninzi begazi kunye nendawo yesiphumo kwaye kuye kwaveliswa iinkqubo ezininzi ezizenzekelayo.