Iindaba

Ngo-1968, u-Kruger-Theimer wabonisa indlela imodeli ye-pharmacokinetic enokusetyenziswa ngayo ukuyila iirejimeni zedosi ezisebenzayo. Le Rejimeni ye-Bolus, Ukupheliswa, uTshintsho (BET) ibandakanya:

idosi ye-bolus ibalwe ukuzalisa indawo ephakathi (igazi),

ukufakwa kwesantya esingaguqukiyo esilingana nesantya sokuphelisa,

ukufakwa okuhlawulela ukudluliselwa kwizicubu ezijikelezayo: [izinga elihla ngokukhawuleza]

Uqheliselo lwemveli lubandakanya ukubala irejimeni yokufakwa kwipropofol ngendlela yeRoberts. I-1.5 mg / kg i-dose yokulayisha ilandelwa yi-infusion ye-10 mg / kg / iyure eyancipha ukuya kumazinga e-8 kunye ne-6 mg / kg / hr kwimizuzu elishumi.

Isiphumo sokujoliswa kwesiza

Iziphumo eziphambili zei-anestheticIi-agent ezifakwa kwi-intravenous ziziphumo zokuthomalalisa kunye ne-hypnotic kunye nesiza apho ichiza lenza ezi ziphumo, zibizwa ngokuba yindawo yesiphumo yingqondo. Ngelishwa akwenzeki kwiklinikhi ukulinganisa ukugxila kwengqondo [indawo yesiphumo]. Nokuba sinokulinganisa ugxininiso lwengqondo oluthe ngqo, kuya kuba yimfuneko ukwazi ugxininiso lwengingqi oluchanekileyo okanye ugxininiso lwe-receptor apho ichiza lenza isiphumo salo.

Ukufezekisa ugxininiso lwepropofol rhoqo

Lo mzobo ungezantsi ubonisa izinga lokugalela elifunekayo kwisantya esihla ngokukhawuleza emva kwedosi ye-bolus ukuze kugcinwe ukuxinana kwegazi lepropofol. Ikwabonisa i-lag phakathi kwegazi kunye nefuthe lendawo yoxinaniso.