Iindaba

Ngo-1968, uKruger-Theimer wabonisa indlela iimodeli ze-pharmacokinetic ezinokusetyenziswa ngayo ukuyila iirejimeni zedosi ezisebenzayo. Le rejimeni yeBolus, Elimination, Transfer (BET) iqulathe oku kulandelayo:

idosi ye-bolus ebalelwe ukuzalisa indawo ephakathi (yegazi),

ukumnika okulinganayo okulingana nesantya sokukhupha,

ukumnika okuxhasa ukudluliselwa kwizicubu ezingaphandle: [isantya esinciphayo ngokubonakalayo]

Indlela yesintu yayibandakanya ukubala indlela yokufaka i-propofol ngendlela kaRoberts. Idosi yokulayisha ye-1.5 mg/kg ilandelwa kukufakwa kwe-10 mg/kg/iyure okuncitshiswayo kube yi-8 kunye ne-6 mg/kg/iyure ngamaxesha alishumi.

Ukujolisa kwisiza esinefuthe

Iziphumo eziphambili zei-anestheticIiarhente zemithambo yegazi zizinto ezithomalalisayo nezibangela ukunxila kwaye indawo apho iyeza lisebenzisa khona ezi ziphumo, ebizwa ngokuba yindawo yesiphumo yingqondo. Ngelishwa akunakwenzeka kwizonyango ukulinganisa uxinzelelo lobuchopho [indawo yesiphumo]. Nokuba singalinganisa uxinzelelo lobuchopho ngqo, kuya kufuneka sazi amazinga achanekileyo engingqi okanye amazinga e-receptor apho iyeza lisebenzisa khona isiphumo salo.

Ukufikelela kuxinzelelo oluqhubekayo lwepropofol

Umzobo ongezantsi ubonisa izinga lokufakwa elifunekayo ngesantya esinciphayo emva kwedosi ye-bolus ukuze kugcinwe imeko ezinzileyo yoxinzelelo lwe-propofol egazini. Ukwabonisa ukushiyeka phakathi koxinzelelo lwegazi kunye nendawo echaphazelekayo.