Iindaba

Imbali ye-insulion-elawulwa i-insulion

Ukugxininiswa kwethagethi (I-tsci) Ngaba indlela yokufumana iziyobisi ezihlutha i-IV ukufezekisa umsebenzisi oqikelelweyo Kolu hlolo, sichaza imigaqo ye-pharmaconkic ye-TCI, ukuphuhliswa kweenkqubo ze-TCI, kunye nemicimbi yezobuchwephesha nezomthetho ezichazwe kwiPrototype yophuhliso. Sikwachaza ukuqaliswa kweenkqubo ezifumanekayo zekliniki ezikhoyo.

Injongo yazo zonke iindlela zokuhanjiswa kweziyobisi ziyafezekiswa kwaye zigcina ikhondo lexesha lonyango, ngelixa ziphepha iziphumo ezibi. Iziyobisi ze-IV zihlala zinikezelwa zisebenzisa imigaqo esemgangathweni ye-Doss. Ngokwesiqhelo ekuphela kwesigulana isigulana esifakwe kwidosi yimetri ye-mese ubungakanani bobuchule, ngokwesiqhelo ubunzima be-IV Anessetics. Iimpawu zesigulana ezinjengeemvakalelo, ngokwesondo, okanye ukucocwa kwe-creayine zihlala zibandakanyi ngenxa yobudlelwane bemathematics olwenziwe bubunzima be-covariates ukuya kwidosi. Ngokwembali bekukho iindlela ezi-2 zokulawula iziyobisi ze-IV ngexesha lokusebenza Iidosi zeBos zilawulwa nge-siringe ephendbileyo. Ukupheliswa kulawulwa ngempompo yenzuzo.

Lonke iziyobisi ze-anesthetic zifundisa kwizicubu ngexesha lokuhanjiswa kweziyobisi. Oku kuqhutywa kolwalamano phakathi kwenqanaba le-insusurion ebekwe ngugqirha kunye nokugxilwa kweziyobisi kwisigulana. Ireyithi ye-propofol ye-100 μg / kg / min inxulunyaniswa nemizuzu emi-3 ephaphile i-3 kwimizuzu ephangiweyo kunye ne-superd okanye i-SUDE eleleyo okanye i-SURE eLongezo. Ngokusebenzisa imigaqo-siseko ye-pharmacokinic (Pk), iikhompyuter zinokubala ukuba zingakanani iziyobisi eziqokelele izicubu ngexesha losulelo kwaye zinokulungelelanisa i-insulions ukugcina uxinzelelo oluzinzileyo kwiplasma okanye izicubu zengqondo, ngokuqhelekileyo ingqondo. Ikhompyuter iyakwazi ukusebenzisa eyona modeli ilungileyo evela kuncwadi, ngenxa yokuba ubunzima bemathematics bezinto ezinesigulana (ubunzima, ubude be-biomaskisi) zibalwa kwe-bivitic) zibalwa sisithathu sokuhambisa iziyobisi, i-incluon egxininiswa kakhulu (i-TCI). Ngeenkqubo ze-TCI, ugqirha wekliniki ungena kwi-ofisi ekujoliswe kuyo enqwenelekayo. Ikhompyuter ibala inani leziyobisi, linikelwe njenge-bosles kunye nokuncitshiswa, kufuneka kufezekiswe ukugxila kwethagethi kwaye ikhokele impompo yenzuzo yokuhambisa i-bolus ebaliweyo okanye i-insulion ebaliweyo. Ikhompyuter ihlala ibala ukuba ingakanani ichiza kwizicubu kwaye kanye indlela efutho ngayo isixa seziyobisi esifunekayo ukufezekisa uxinzelelo lwe-Pks ekhethiweyo kunye nezigulana.

Ngexesha lotyando, inqanaba lokukhuthaza ukunyuka linokutshintsha ngokukhawuleza, lifuna i-precie, isishumi sempembelelo yeziyobisi. Ukuncitshiswa okuqhelekileyo akunakukhulisa ukugxila kweziyobisi ngokukhawuleza ngokukhawuleza ukufumana i-akhawunti yokuqhubela phambili ekukhuthazeni okanye ukwehla kokugxila ngokukhawuleza ngokwaneleyo ukuba ikhuphe amaxesha aphezulu. Ukuncipha okuqhelekileyo akunakukwazi nokugcina ukugxininisa iziyobisi kwiplasma okanye ingqondo ngexesha lokuvuselela rhoqo. Ngokubandakanya iimodeli ze-PK, iinkqubo ze-TCI zinokuphendula ngokukhawuleza ngakumbi njengoko kufuneka kwaye zihlale zilungiswe ngokufanayo xa kufanelekile. Isibonelelo esinokubakho kwiiKlinikisi zezona zityholo zichanekileyo zef.3

Kolu phononongo, sichaza imigaqo-siseko ye-TCI, ukuphuhliswa kweenkqubo ze-TCI, kunye nezobuchwephesha kunye nemicimbi yezobugcisa ebekiweyo kuPhuhliso lwePrototype. Amanqaku amabini ahamba kunye nawo ahamba kunye nawo ahamba kunye nawo ahamba kunye nemiba yehlabathi enxulumene nale teknoloji.4,5

Njengoko iinkqubo ze-TCI zavela, abaphandi bakhetha amagama e-idiosyncracy yenkqubo. Iinkqubo ze-TCI zidluliselwe kwi-IV encediswa yikhompyuter ye-IV Anesthesia (Catia), isibonelelo esi-6 se-IV ye-IV ye-IV CORMENITION, i-CIAC), i-CACE), i-CIAC-i-7 kunye neKhompyuter i-7 kunye neKhompyuter isebenze ngo-1997 phakathi kwexesha Inkcazo eqhelekileyo yetekhnoloji.10