Iimodeli ze-pharmacokinetic ezilawulwa yikhompyuter
Ukusebenzisa ai-pharmacokineticimodeli, ikhomputha ibala ngokuqhubekayo uxinaniso lweziyobisi olulindelekileyo lwesigulane kwaye ilawula irejimeni ye-BET, ilungelelanisa amazinga okufakwa kwempompo, ngokuqhelekileyo kwizithuba ze-10-yesibini. Iimodeli zithathwe kwizifundo ze-pharmacokinetic zabemi ezenziwe ngaphambili. Ngokucwangcisa ugxininiso olunqwenelekayo ekujoliswe kulo, ii-anesthetistisebenzisa ifowuni ngendlela efana ne-vaporizer. Kukho iiyantlukwano phakathi koxinaniso oluqikelelweyo kunye nolwenyani, kodwa ezi azinasiphumo esikhulu, ngaphandle kokuba ugxininiso lokwenyani lungaphakathi kwefestile yonyango yechiza.
I-pharmacokinetics yesigulana kunye ne-pharmacodynamics iyahluka ngokweminyaka, ukuphuma kwentliziyo, isifo esihlala sihlala, ukulawulwa kweziyobisi kunye, ubushushu bomzimba kunye nobunzima besigulane. Ezi zinto zidlala indima ebalulekileyo ekukhetheni ugxininiso ekujoliswe kulo.
UVaughan Tucker uphuhlise inkqubo yokuqala yokuncedisa i-IV ye-anesthetic system [CATIA]. Eyokuqala yorhweboukufakwa okujoliswe kuko okulawulwayoisixhobo yayiyi-Diprufusor eyaziswa ngu-Astra Zeneca, ezinikele kulawulo lwepropofol phambi kwesirinji yepropofol ezaliswe ngaphambili kunye nomcu wemagnethi kwiflange yayo. Iinkqubo ezininzi ezintsha ziyafumaneka ukuze zisetyenziswe ngoku. Idatha yesigulane njengobunzima, ubudala kunye nokuphakama zicwangciswe kwimpompo kunye nesofthiwe yepompo, ngokusebenzisa ukulinganisa kwe-pharmacokinetic, ngaphandle kokulawula nokugcina amazinga afanelekileyo okufakwa, kubonisa ukugxininiswa okubalwe kunye nexesha elilindelekileyo lokubuyisela.
Ixesha lokuposa: Dec-10-2024