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Iimodeli ze-pharmacokinetic ezilawulwa yikhompyutha

Ukusebenzisai-pharmacokineticimodeli, ikhompyutha ibala rhoqo uxinaniso lweyeza olulindelekileyo kwisigulane kwaye inike irejimeni ye-BET, ilungisa amazinga okufakwa kwepompo, ngesiqhelo kwisithuba semizuzwana eli-10. Iimodeli zithathwe kwizifundo ze-pharmacokinetic zabantu ezenziwe ngaphambili. Ngokucwangcisa uxinaniso olufunekayo,ingcali yokunciphisa iintlunguisebenzisa esi sixhobo ngendlela efana ne-vaporizer. Kukho umahluko phakathi koxinzelelo oluqikelelweyo nolokwenyani, kodwa olu xinzelelo alunamsebenzi mkhulu, ukuba nje uxinzelelo lokwenyani lukwifestile yonyango yeziyobisi.

I-pharmacokinetics kunye ne-pharmacodynamics yesigulane ziyahluka ngokweminyaka, amandla entliziyo, isifo esihlala kunye, ukusetyenziswa kwamayeza ngaxeshanye, ubushushu bomzimba kunye nobunzima bomguli. Ezi zinto zidlala indima ebalulekileyo ekukhetheni ugxininiso ekujoliswe kulo.

UVaughan Tucker waphuhlisa inkqubo yokuqala yokubulala iintlungu ye-total IV encediswa yikhompyutha [CATIA]. Intengiso yokuqalaukufakwa okujoliswa ekujoliswe kukoIsixhobo yayiyiDiprufusor eyaziswa yiAstra Zeneca, eyayizinikele ekusetyenzisweni kwepropofol phambi kwesirinji yepropofol ezaliswe kwangaphambili ene-magnetic strip kwiflange yayo. Iinkqubo ezininzi ezintsha ziyafumaneka ukuze zisetyenziswe ngoku. Idatha yesigulana efana nobunzima, ubudala kunye nobude icwangcisiwe kwipompo kwaye isoftware yepompo, ngokusebenzisa i-pharmacokinetic simulation, ngaphandle kokulawula kunye nokugcina amazinga afanelekileyo okufakwa, ibonisa amazinga abaliweyo kunye nexesha elilindelekileyo lokuchacha.